Why would either of these things be a reason why two people aren't compatable. Just because someone isn't "conventially attractive," doesn't mean that two people can't feel attraction towards each other.
Back on the topic of the original topic, this kind of thing is terrible in my opinion. As a male presenting individual with mostly female friends, I constantly face the "are you two dating?" question and I'm sick of it. I don't see why males and females can't just be friends without the fear of the other person being attracted to them. If that is the case, then it shouldn't just automatically ruin the friendship.